RNAi is a mechanism explaining the production of small RNAs of about twenty one nucleotides derived from the virus, which are then used as guides for targeting very specifically a RNase from the Argonaute family to the viral RNAs, which will be neutralized selectively. We are interested in understanding three main points during viral infection:
How viruses are recognized by the exonuclease Dicer-2?
What are the antiviral complexes in opposite to RNAi pathway?
What are the dynamics of the antiviral innate immunity?
The team is composed of a permanent member from the University of Strasbourg (Carine Meignin, associate professor), working with post-doctoral fellows and technicians supported by grants, PhD and Master students.
In addition, since 2012, a collaboration with the group of J. Marques in Belo-Horizonte (Brazil) allows to extend the work on flies to Aedes vector mosquitoes, which transmit viruses such as Dengue or Chikungunya to humans.
Keywords: Drosophila melanogaster, virus, innate immunity, viral RNA, nucleic acid receptors, small RNA, RNA interference, selective translation.
Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS. In: G3 (Bethesda), 2017, ISSN: 2160-1836.
Discovery of novel targets for antivirals: learning from flies. In: Curr Opin Virol, 20 , pp. 64–70, 2016, ISSN: 1879-6265.
Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity. In: J. Virol., 90 (11), pp. 5415–5426, 2016, ISSN: 0022-538X, 1098-5514.
WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity. In: Fly (Austin), 10 (4), pp. 187–194, 2016, ISSN: 1933-6942.
Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host. In: Nucleic Acids Research, 43 (13), pp. 6191–6206, 2015, ISSN: 1362-4962.
Sensing viral RNAs by Dicer/RIG-I like ATPases across species. In: Current Opinion in Immunology, 32 , pp. 106–113, 2015, ISSN: 1879-0372.
Cross-species comparative analysis of Dicer proteins during Sindbis virus infection. In: Scientific Reports, 5 , pp. 10693, 2015, ISSN: 2045-2322.