Research focus

RNAi is a mechanism explaining the production of small RNAs of about twenty one nucleotides derived from the virus, which are then used as guides for targeting very specifically a RNase from the Argonaute family to the viral RNAs, which will be neutralized selectively. We are interested in understanding three main points during viral infection:
  • How viruses are recognized by the exonuclease Dicer-2?
  • What are the antiviral complexes in opposite to RNAi pathway?
  • What are the dynamics of the antiviral innate immunity?
The team is composed of a permanent member from the University of Strasbourg (Carine Meignin, associate professor), working with post-doctoral fellows and technicians supported by grants, PhD and Master students.
In addition, since 2012, a collaboration with the group of J. Marques in Belo-Horizonte (Brazil) allows to extend the work on flies to Aedes vector mosquitoes, which transmit viruses such as Dengue or Chikungunya to humans.

 

KeywordsDrosophila melanogaster, virus, innate immunity, viral RNA, nucleic acid receptors, small RNA, RNA interference, selective translation. 

 

Recent Publications

Lauriane Kuhn, Karim Majzoub, Evelyne Einhorn, Johana Chicher, Julien Pompon, Jean-Luc Imler, Philippe Hammann, Carine Meignin: Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS. In: G3 (Bethesda), 2017, ISSN: 2160-1836.

Nelson Martins, Jean-Luc Imler, Carine Meignin: Discovery of novel targets for antivirals: learning from flies. In: Curr Opin Virol, 20 , pp. 64–70, 2016, ISSN: 1879-6265.

Olivier Lamiable, Johan Arnold, Isaque Joao da Silva de Faria, Roenick Proveti Olmo, Francesco Bergami, Carine Meignin, Jules A. Hoffmann, Joao Trindade Marques, Jean-Luc Imler: Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity. In: J. Virol., 90 (11), pp. 5415–5426, 2016, ISSN: 0022-538X, 1098-5514.

Olivier Lamiable, Carine Meignin, Jean-Luc Imler: WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity. In: Fly (Austin), 10 (4), pp. 187–194, 2016, ISSN: 1933-6942.

Eric Roberto Guimarães Rocha Aguiar, Roenick Proveti Olmo, Simona Paro, Flavia Viana Ferreira, Isaque João da Silva de Faria, Yaovi Mathias Honore Todjro, Francisco Pereira Lobo, Erna Geessien Kroon, Carine Meignin, Derek Gatherer, Jean-Luc Imler, João Trindade Marques: Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host. In: Nucleic Acids Research, 43 (13), pp. 6191–6206, 2015, ISSN: 1362-4962.

Simona Paro, Jean-Luc Imler, Carine Meignin: Sensing viral RNAs by Dicer/RIG-I like ATPases across species. In: Current Opinion in Immunology, 32 , pp. 106–113, 2015, ISSN: 1879-0372.

Erika Girardi, Mathieu Lefèvre, Béatrice Chane-Woon-Ming, Simona Paro, Bill Claydon, Jean-Luc Imler, Carine Meignin, Sébastien Pfeffer: Cross-species comparative analysis of Dicer proteins during Sindbis virus infection. In: Scientific Reports, 5 , pp. 10693, 2015, ISSN: 2045-2322.