In humans, the inflammatory response when deregulated may lead to the occurrence of chronic inflammatory diseases and cancer development. The development of molecules able to interfer with the abnormal activation of NF-kB pathways, without the toxic effects associated with currently used anti-inflammatory, is indissociable from a better understanding of NF-kB signaling pathway and their operations. Also the goal of our group is to decode the NF-kB pathway to understand their regulation mechanisms. To do this we use genetic and proteomic approaches adapted to the Drosophila model and in human cell cultures.
Downstream NF-kB signaling pathways activated by inflammatory stimuli, the NF-kB transcription factors play a central role. They are responsible for hundreds of gene activation pro- or anti-inflammatory activity.
Publication of the team