Group leader: Dominique FERRANDON
Deciphering the molecular pathways involved in host-pathogen interactions

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We aim to decipher the molecular mechanisms allowing a host and a pathogen to adapt each other:
– the host attacking the pathogen (resistance) or defending and repairing itself (resilience)
– the pathogen hijacking the host defences or simply hiding itself, and sometimes attacking the host.
We work from both the host side (drosophila) and the pathogen side (bacteria and fungi).

Research projects

We are mainly focused on the epithelial barrier of the intestine, in infection models using Gram-negative bacteria (Serratia marcescens and Pseudomonas aeruginosa). We also study systemic effects with a parasitic infection model (the microsporidium Tubulinosema ratisbonensis).

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The Ferrandon group

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We are a very motivated small group, working all together in a helpful and enthusiastic atmosphere.

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Our publications


Sascha Brunke, Jessica Quintin, Lydia Kasper, Ilse D. Jacobsen, Martin E. Richter, Ekkehard Hiller, Tobias Schwarzmüller, Christophe d'Enfert, Karl Kuchler, Steffen Rupp, Bernhard Hube, Dominique Ferrandon: Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts. In: Dis Model Mech, 8 (5), pp. 473–486, 2015, ISSN: 1754-8411.

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